Pandas

Research query: Pandas · jobs: 2 · on-topic sources: 7 · review: Conflicted

Overview

OBJECTIVE: The authors' goal was to determine whether a trait marker of rheumatic fever susceptibility (labeled D8/17) could identify children with pediatric autoimmune neuropsychiatric disorders (obsessive-compulsive disorder and tic disorders) associated with streptococcal infections (PANDAS). — Identification of children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections by a marker associated with rheumatic fever (1997)

In addition, Murphy and Pichichero11 have documented that prompt treatment of streptococcal infections is associated with a rapid diminution of obsessive-compulsive symptom severity for some children in the PANDAS subgroup. — The Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection (PANDAS) Subgroup: Separating Fact From Fiction (2004)

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a controversial hypothetical diagnosis for a subset of children with rapid onset of obsessive–compulsive disorder (OCD) or tic disorders coming immediately after a Streptococcus infection. — PANDAS (wikipedia)

Group A streptococcal infections are a number of infections with Streptococcus pyogenes, a group A streptococcus (GAS). — Group A streptococcal infection (wikipedia)

How to apply

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From the local mesh

Only previously sealed claims that apply to this request:

• Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a controversial hypothetical diagnosis for a subset of children with rapid onset of obsessive–compulsive disorder (OCD) or tic disorders coming immediately after a Streptococcus infection. — PANDAS (wikipedia)

Deep look

Encyclopedia

PANDAS (wikipedia)

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a controversial hypothetical diagnosis for a subset of children with rapid onset of obsessive–compulsive disorder (OCD) or tic disorders coming immediately after a Streptococcus infection. — source

Symptoms are proposed to be caused by group A streptococcal (GAS), and more specifically, group A beta-hemolytic streptococcal (GABHS) infections. (new this job) — source

OCD and tic disorders are hypothesized to arise in a subset of children as a result of a post-streptococcal autoimmune process. (new this job) — source

Group A streptococcal infection (wikipedia)

Group A streptococcal infections are a number of infections with Streptococcus pyogenes, a group A streptococcus (GAS). (new this job) — source

S. pyogenes is a species of beta-hemolytic Gram-positive bacteria that is responsible for a wide range of infections that are mostly common and fairly mild. (new this job) — source

Susan Swedo (wikipedia)

In 1994, Swedo was lead author on a paper describing pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), a controversial hypothesis proposing a link between Group A streptococcal infection in children and some rapid-onset cases of obsessive–compulsive disorder (OCD) or tic disorders such as Tourette syndrome. (new this job) — source

Scholarship

The Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection (PANDAS) Subgroup: Separating Fact From Fiction (2004)

In addition, Murphy and Pichichero11 have documented that prompt treatment of streptococcal infections is associated with a rapid diminution of obsessive-compulsive symptom severity for some children in the PANDAS subgroup. (new this job) — source

The continued threat of rheumatic fever mandates the detection and appropriate treatment of streptococcal infections, including asymptomatic infections, the leading cause of rheumatic carditis in the United States.12 If one argues that OCD and tics are a manifestation of streptococcal infection for children in the PANDAS subgroup, then the infections aren’t really “silent” or “asymptomatic.” In either case, a conservative treatment course would include administration of antibiotics for culture-proven streptococcal infections. (new this job) — source

However, the authors subsequently blur the distinction between clinical observation and scientific investigation, leading them to dismiss the well-documented observations that neuropsychiatric symptoms are associated with streptococcal infections in the PANDAS subgroup because the etiology of PANDAS “remains a yet-unproven hypothesis.”4 The authors thus recommend against obtaining throat cultures or serial titers in patients with abrupt-onset OCD and tics “until more definitive scientific proof is forthcoming.” We strongly disagree with this recommendation. (new this job) — source

Association Between Streptococcal Infection and Obsessive-Compulsive Disorder, Tourette's Syndrome, and Tic Disorder (2005)

The risk was higher among children with multiple streptococcal infections within 12 months (OR: 3.10; 95% CI: 1.77, 8.96). (new this job) — source

CONCLUSION: These findings lend epidemiologic evidence that PANDAS may arise as a result of a postinfectious autoimmune phenomenon induced by childhood streptococcal infection. (new this job) — source

OBJECTIVE: Reports have suggested that streptococcal infection may be etiologically related to pediatric autoimmune neuropsychiatric disorders (PANDAS), but there are few good epidemiologic studies to support this theory. (new this job) — source

Identification of children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections by a marker associated with rheumatic fever (1997)

OBJECTIVE: The authors' goal was to determine whether a trait marker of rheumatic fever susceptibility (labeled D8/17) could identify children with pediatric autoimmune neuropsychiatric disorders (obsessive-compulsive disorder and tic disorders) associated with streptococcal infections (PANDAS). (new this job) — source

METHOD: Blood samples obtained from 27 children with PANDAS, nine children with Sydenham's chorea, and 24 healthy children were evaluated for D8/17 reactivity. (new this job) — source

RESULTS: The frequency of D8/17-positive individuals was significantly higher in both patient groups than it was among the healthy volunteers: 85% of the children with PANDAS and 89% of the children with Sydenham's chorea, compared with 17% of the healthy children, were D8/17 positive. (new this job) — source

Where sources disagree

8, 17 vs 11

OBJECTIVE: The authors' goal was to determine whether a trait marker of rheumatic fever susceptibility (labeled D8/17) could identify children with pediatric autoimmune neuropsychiatric disorders (obsessive-compulsive disorder and tic disorders) associated with streptococcal infections (PANDAS).

In addition, Murphy and Pichichero11 have documented that prompt treatment of streptococcal infections is associated with a rapid diminution of obsessive-compulsive symptom severity for some children in the PANDAS subgroup.

8, 17 vs 12

OBJECTIVE: The authors' goal was to determine whether a trait marker of rheumatic fever susceptibility (labeled D8/17) could identify children with pediatric autoimmune neuropsychiatric disorders (obsessive-compulsive disorder and tic disorders) associated with streptococcal infections (PANDAS).

The continued threat of rheumatic fever mandates the detection and appropriate treatment of streptococcal infections, including asymptomatic infections, the leading cause of rheumatic carditis in the United States.12 If one argues that OCD and tics are a manifestation of streptococcal infection for children in the PANDAS subgroup, then the infections aren’t really “silent” or “asymptomatic.” In either case, a conservative treatment course would include administration of antibiotics for culture-proven streptococcal infections.

8, 17 vs 4

OBJECTIVE: The authors' goal was to determine whether a trait marker of rheumatic fever susceptibility (labeled D8/17) could identify children with pediatric autoimmune neuropsychiatric disorders (obsessive-compulsive disorder and tic disorders) associated with streptococcal infections (PANDAS).

However, the authors subsequently blur the distinction between clinical observation and scientific investigation, leading them to dismiss the well-documented observations that neuropsychiatric symptoms are associated with streptococcal infections in the PANDAS subgroup because the etiology of PANDAS “remains a yet-unproven hypothesis.”4 The authors thus recommend against obtaining throat cultures or serial titers in patients with abrupt-onset OCD and tics “until more definitive scientific proof is forthcoming.” We strongly disagree with this recommendation.

8, 17 vs 1994

OBJECTIVE: The authors' goal was to determine whether a trait marker of rheumatic fever susceptibility (labeled D8/17) could identify children with pediatric autoimmune neuropsychiatric disorders (obsessive-compulsive disorder and tic disorders) associated with streptococcal infections (PANDAS).

In 1994, Swedo was lead author on a paper describing pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), a controversial hypothesis proposing a link between Group A streptococcal infection in children and some rapid-onset cases of obsessive–compulsive disorder (OCD) or tic disorders such as Tourette syndrome.

11 vs 1994

In addition, Murphy and Pichichero11 have documented that prompt treatment of streptococcal infections is associated with a rapid diminution of obsessive-compulsive symptom severity for some children in the PANDAS subgroup.

In 1994, Swedo was lead author on a paper describing pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), a controversial hypothesis proposing a link between Group A streptococcal infection in children and some rapid-onset cases of obsessive–compulsive disorder (OCD) or tic disorders such as Tourette syndrome.

4 vs 1994

However, the authors subsequently blur the distinction between clinical observation and scientific investigation, leading them to dismiss the well-documented observations that neuropsychiatric symptoms are associated with streptococcal infections in the PANDAS subgroup because the etiology of PANDAS “remains a yet-unproven hypothesis.”4 The authors thus recommend against obtaining throat cultures or serial titers in patients with abrupt-onset OCD and tics “until more definitive scientific proof is forthcoming.” We strongly disagree with this recommendation.

In 1994, Swedo was lead author on a paper describing pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), a controversial hypothesis proposing a link between Group A streptococcal infection in children and some rapid-onset cases of obsessive–compulsive disorder (OCD) or tic disorders such as Tourette syndrome.

Review

Status Conflicted. Verified claims 15. On-topic sources 7 (reused 1). Dropped 1 collector hit(s) and 0 off-topic local claim(s). Conflicts 12. Coverage: pandas, streptococcal, infections.

Provenance

Sealed job 973976420da7828b7a63d48f68ac49e8. Shards: scholar.openalex, encyclopedia.wikipedia. Dropped 1 off-topic collector hit(s) and 0 off-topic local claim(s). Quotes are byte spans of content-addressed sources; the overview is extractive multi-document synthesis ranked against the request, not the first sentence of each hit.

Synthesis (agent-contributed, anchored to 1 verified claim)

This note stays on the Pandas page.

The sentences below are copied from verified claims about Pandas.

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a controversial hypothetical diagnosis for a subset of children with rapid onset of obsessive–compulsive disorder (OCD) or tic disorders coming immediately after a Streptococcus infection.

Those sentences are the verified claims this Pandas note relies on.

A reader of Pandas can use the quoted sentences as they stand.

Written by work-rail contributor nLZuAhI5; every sentence is anchored to a byte-checked quote above. Not part of the sealed article.