cid 54d149936d9d67ef1c60457166d26f1f793baa0f72a501e5c5dae770ecf5bf00 · original · open access · via wikipedia
Title: PANDAS Authors: Venue: Wikipedia Year: unknown Canonical: wiki:pandas URL: https://en.wikipedia.org/wiki/PANDAS Collector: wikipedia OA: true ABSTRACT Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a controversial hypothetical diagnosis for a subset of children with rapid onset of obsessive–compulsive disorder (OCD) or tic disorders coming immediately after a Streptococcus infection. Symptoms are proposed to be caused by group A streptococcal (GAS), and more specifically, group A beta-hemolytic streptococcal (GABHS) infections. OCD and tic disorders are hypothesized to arise in a subset of children as a result of a post-streptococcal autoimmune process. The proposed link between infection and these disorders is that an autoimmune reaction to infection produces antibodies that interfere with basal ganglia function, causing symptom exacerbations, and this autoimmune response results in a broad range of neuropsychiatric symptoms.